Susten 100 mg Injection (Progesterone) – Product Overview

Susten 100 mg injection is a pharmaceutical formulation containing progesterone, a synthetic analogue of the natural hormone progesterone. Manufactured by Sun Pharmaceutical Industries Ltd, the product is supplied in a sterile aqueous solution for intramuscular administration. Each ampule contains 100 mg of progesterone in a 1 ml volume, while vials provide 2 ml per unit. The medication is indicated for the treatment of female infertility and as part of hormone replacement therapy in selected clinical situations.

What is Susten 100 mg Injection?

Progesterone plays a critical role in regulating the menstrual cycle, preparing the uterine lining for implantation, and maintaining early pregnancy. In clinical practice, exogenous progesterone such as Susten is used to address luteal phase deficiency, support assisted reproductive technologies, and provide systemic hormone replacement in post‑menopausal women who require estrogen‑based therapy but also need progestogenic protection. The active ingredient is chemically identical to endogenous progesterone, ensuring compatibility with the body’s receptor sites.

Uses and Benefits

The primary therapeutic use of Susten 100 mg injection is to support ovulation induction in women undergoing fertility treatment. By supplementing progesterone levels during the luteal phase, the drug enhances endometrial receptivity, thereby increasing the likelihood of successful implantation after in‑vitro fertilisation or controlled ovarian hyperstimulation. In hormone replacement regimens, Susten provides the necessary progestogenic component to counteract estrogen‑driven endometrial proliferation, reducing the risk of endometrial hyperplasia and carcinoma in women who have not undergone hysterectomy.

How It Works

After administration, the injected progesterone is absorbed into the systemic circulation and binds to intracellular progesterone receptors in target tissues. This interaction modulates gene transcription, leading to the production of proteins that prepare the endometrium for implantation and maintain pregnancy. The pharmacodynamic profile of Susten is characterized by a relatively slow onset and a prolonged duration of action, which is advantageous for sustaining luteal support over several days.

Dosage Guidelines

Dosage of Susten 100 mg injection is generally determined by the clinical indication and patient response. For ovulation induction, a typical regimen involves a single intramuscular dose of 100 mg administered every 2 to 3 days during the luteal phase, continuing until a confirmed pregnancy or until the prescribed treatment window expires. In hormone replacement therapy, the recommended dose may be 100 mg administered every 2 to 3 days, adjusted based on the attending physician’s assessment of the patient’s hormonal status and tolerability. Patients should always follow the dosing schedule prescribed by their healthcare provider and should not modify the frequency without professional guidance.

Side Effects

Like all medicinal products, Susten 100 mg injection may cause adverse effects. Commonly reported side effects include mild to moderate pain or irritation at the injection site, headache, abdominal discomfort, and transient breast tenderness. Less frequent but clinically significant events can involve allergic reactions, dizziness, or changes in mood. Rarely, patients may experience venous thromboembolic phenomena, especially when combined with estrogen therapy, which necessitates immediate medical evaluation. Any unexpected or severe symptoms should prompt discontinuation of the medication and consultation with a qualified clinician.

Warnings and Precautions

Susten is contraindicated in patients with known hypersensitivity to progesterone or any excipients present in the formulation. It should be used with caution in individuals with a history of thromboembolic disorders, liver disease, or unexplained vaginal bleeding. Concomitant use with estrogen therapy requires careful monitoring for signs of endometrial hyperplasia. Pregnant women should not receive Susten unless specifically indicated for luteal support, and breastfeeding mothers should discuss potential risks with their physician. Routine laboratory monitoring, including liver function tests and lipid profiles, may be advisable for long‑term users.

Frequently Asked Questions

1. What is the primary indication for Susten 100 mg injection? It is primarily used to support ovulation in women undergoing fertility treatments and to provide progestogenic protection in hormone replacement therapy.
2. How should Susten be stored? Store the ampules or vials at a controlled room temperature, protected from light and moisture. Do not freeze the medication.
3. Can Susten be self‑administered at home? Administration should be performed by a qualified healthcare professional or under direct supervision to ensure proper technique and aseptic handling.
4. Is Susten compatible with oral contraceptives? Because both agents influence hormonal balance, concurrent use should only occur under medical supervision to avoid unpredictable interactions.
5. What should I do if I miss a scheduled dose? If a dose is missed, contact your healthcare provider for guidance; do not double the dose to compensate.

For additional scientific detail and regulatory information, refer to resources such as the National Institutes of Health and the U.S. Food and Drug Administration.

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